Humanin 5mg 10mL Vial
£295.00
MOA
- Mitochondrial-Derived Cytoprotective Peptide:
- Humanin is a 24–amino acid mitochondrial-derived peptide (MDP) that functions as a potent cytoprotective and neuroprotective signaling molecule. It operates through both intracellular and extracellular mechanisms to preserve mitochondrial integrity, enhance stress resilience, and activate longevity-associated pathways.
- Intracellular Mitochondrial Stabilization:
- Within the cell, Humanin binds to pro-apoptotic Bcl-2 family proteins such as Bax, tBid, and Bak. This binding inhibits their translocation to the mitochondrial outer membrane, preventing cytochrome c release and apoptosis. By maintaining mitochondrial membrane potential, Humanin preserves ATP production and cellular energy metabolism under oxidative or inflammatory stress.
- Extracellular Receptor-Mediated Signaling:
- Extracellularly, Humanin functions in a hormone-like manner by binding to a trimeric receptor complex composed of CNTFR, WSX-1, and gp130. This interaction activates pro-survival signaling cascades including STAT3, PI3K/Akt, and ERK1/2, which enhance cell survival, inhibit inflammatory signaling, and mitigate oxidative injury.
- Neuroprotective and Anti-Apoptotic Effects:
- Humanin confers protection against neurotoxic and amyloidogenic stress by reducing oxidative damage and inhibiting apoptotic pathways. These neuroprotective mechanisms have been shown to preserve neuronal viability and function in models of Alzheimer’s disease, ischemia, and age-related neurodegeneration.
- Mitochondrial Biogenesis and Redox Regulation:
- By modulating mitochondrial biogenesis and reducing reactive oxygen species (ROS) accumulation, Humanin enhances mitochondrial quality control and cellular redox balance. These effects promote improved energy metabolism, stress adaptation, and protection against mitochondrial dysfunction.
- Metabolic and Endocrine Effects:
- Systemically, Humanin exerts endocrine-like actions across multiple organs—including the brain, heart, skeletal muscle, and pancreas. It improves glucose utilization, supports insulin sensitivity, and contributes to overall metabolic stability. These coordinated effects align Humanin with key longevity and homeostatic signaling pathways.
More Information
- Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.
